Ethynylbenzene compounds and derivatives thereof

Details Ethynylbenzene compounds and derivatives thereof Ethynylbenzene compounds and derivatives thereof

C - Chemistry, Metallurgy

07

C

260/653.2

C07C 327/00 (2006.01) C07C 1/24 (2006.01) C07C 13/28 (2006.01) C07C 15/48 (2006.01) C07C 17/00 (2006.01) C07C 17/25 (2006.01) C07C 22/04 (2006.01) C07C 25/24 (2006.01) C07C 45/30 (2006.01) C07C 47/55 (2006.01) C07C 57/62 (2006.01) C07C 59/88 (2006.01) C07C 59/90 (2006.01) C07C 205/12 (2006.01) C07C 205/56 (2006.01)

Patent

CA 1084521

ABSTRACT OF THE DISCLOSURE An ethynyl benzene compound of the formula Image which has analgesic and antipyretic activities is produced (a) by splitting off carbon dioxide from a propiolic acid of the formula Image or (b) by subjecting a compound of the formula ' Image to a hydrogen-halide splitting off treatment. In the above formulae, R is alkyl, cycloalkyl, alkylcycloalkyl, cycloalkanyl, aryl or substituted aryl, in which the substituent is Y", and Y, Y' and Y" are hydrogen, alkyl, halo, nitro, amino, acylamino, mono- and diloweralkylamino, mercapto, acylthio, lower alkylthio, lower alkylsulfinyl, lower alkylsulfonyl, hydroxy, lower alkoxy, acyloxy, haloloweralkyl, cyano or acetyl, with the proviso that when R is phenyl, at least one of Y, Y' and Y" are other than hydrogen, and Hal represents a halogen.

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