Ethynylphenyl derivative substituted by pyridazinone and...

C - Chemistry – Metallurgy – 07 – D

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C07D 401/12 (2006.01) A61K 31/50 (2006.01) A61K 31/535 (2006.01) C07D 401/14 (2006.01) C07D 413/14 (2006.01)

Patent

CA 2069877

ABSTRACT There are disclosed an ethynylphenyl derivative substituted by pyridazinone having the formula (I): Image (I) wherein R1 is hydrogen atom, a C1-6 alkyl group, a C1-4 alkoxycarbonyl group, a substituted amino C1-6 alkyl group, a hydroxy C1-4 alkyl group or a phenyl group substituted by an alkyl group, an alkoxyl group, nitro group or a halogen atom, R2 is hydrogen atom, a C1-4 alkoxyl group, or a halogen atom, R3 is a C1-4 alkoxyl group, a C1-6 alkylamino group or a C1-4 alkoxy C1-4 alkoxyl group, R4 is a C1-4 alkyl group or amino group, R5 is hydrogen atom or a C1-4 alkyl group, R6 is hydrogen atom or a C1-4 alkyl group, and R7 is hydrogen atom or a C1-4 alkyl group, which may be a racemic modification or an optical isomer, or a pharmacologically acceptable salt thereof, a medicament for a circulatory disease comprising the above-mentioned ethynylphenyl derivative substituted by pyridazinone or the pharmacologically acceptable salt thereof as an effective ingredient, a medicament for thrombosis comprising the above-mentioned ethynylphenyl derivative substituted by pyridazinone or the pharmacologically acceptable salt thereof as an effective ingredient and a medicament for a kidney disease comprising the above-mentioned ethynylphenyl derivative substituted by pyridazinone or the pharmacologically acceptable salt thereof as an effective ingredient.

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