C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 401/12 (2006.01) A61K 31/50 (2006.01) A61K 31/535 (2006.01) C07D 401/14 (2006.01) C07D 413/14 (2006.01)
Patent
CA 2069877
ABSTRACT There are disclosed an ethynylphenyl derivative substituted by pyridazinone having the formula (I): Image (I) wherein R1 is hydrogen atom, a C1-6 alkyl group, a C1-4 alkoxycarbonyl group, a substituted amino C1-6 alkyl group, a hydroxy C1-4 alkyl group or a phenyl group substituted by an alkyl group, an alkoxyl group, nitro group or a halogen atom, R2 is hydrogen atom, a C1-4 alkoxyl group, or a halogen atom, R3 is a C1-4 alkoxyl group, a C1-6 alkylamino group or a C1-4 alkoxy C1-4 alkoxyl group, R4 is a C1-4 alkyl group or amino group, R5 is hydrogen atom or a C1-4 alkyl group, R6 is hydrogen atom or a C1-4 alkyl group, and R7 is hydrogen atom or a C1-4 alkyl group, which may be a racemic modification or an optical isomer, or a pharmacologically acceptable salt thereof, a medicament for a circulatory disease comprising the above-mentioned ethynylphenyl derivative substituted by pyridazinone or the pharmacologically acceptable salt thereof as an effective ingredient, a medicament for thrombosis comprising the above-mentioned ethynylphenyl derivative substituted by pyridazinone or the pharmacologically acceptable salt thereof as an effective ingredient and a medicament for a kidney disease comprising the above-mentioned ethynylphenyl derivative substituted by pyridazinone or the pharmacologically acceptable salt thereof as an effective ingredient.
Murata Takahiko
Nagahara Michiko
Nakagawa Terutake
Nakanishi Michio
Nakano Jun
Kaken Pharmaceutical Co. Ltd.
Murata Takahiko
Nagahara Michiko
Nakagawa Terutake
Nakanishi Michio
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