C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/81 (2006.01) A61K 31/704 (2006.01) A61K 31/7048 (2006.01) A61K 47/42 (2006.01) A61K 47/48 (2006.01) A61P 35/00 (2006.01) C07H 15/252 (2006.01) C07H 17/04 (2006.01) C07K 7/08 (2006.01) C07K 14/00 (2006.01) C07K 14/705 (2006.01)
Patent
CA 2740317
The invention relates to improvements in the field of drug delivery. More particularly, the invention relates to polypeptides having a hydrolyzable covalent bond to a therapeutic agent that includes, etoposide, etoposide 4'- dimethylglycine or doxorubicin. These polypeptide conjugates can be used as vectors to transport the podophyllotoxin derivative across the blood brain barrier (BBB) or into particular cell types such as ovary, liver, lung, or kidney. The invention also relates to pharmaceutical compositions that include the compounds of the invention and to uses thereof in methods of treatment.
L'invention concerne des améliorations dans le domaine de l'administration de médicaments. Plus particulièrement, l'invention porte sur des polypeptides qui présentent une liaison covalente hydrolysable avec un agent thérapeutique qui comprend l'étoposide, le 4'-diméthylglycinate d'étoposide ou la doxorubicine. Ces conjugués polypeptidiques peuvent être utilisés comme vecteurs pour transporter le dérivé de podophyllotoxine à travers la barrière hémato-encéphalique (BHE) ou dans des types particuliers de cellules telles que les cellules de l'ovaire, du foie, des poumons ou des reins. L'invention porte également sur des compositions pharmaceutiques qui comprennent les composés de l'invention et sur leurs utilisations dans des procédés de traitement.
Che Christian
Demeule Michel
Gabathuler Reinhard
Yang Gaoqiang
Angiochem Inc.
Goudreau Gage Dubuc
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