C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 5/10 (2006.01) A01K 67/027 (2006.01) A61K 35/12 (2006.01) A61K 38/19 (2006.01) A61K 39/00 (2006.01) C07K 14/705 (2006.01) C07K 14/74 (2006.01) C12N 15/85 (2006.01) C12Q 1/02 (2006.01) G01N 33/566 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2251645
The invention concerns the use of a eukaryotic cell coding for at least an HLA-G isoform, to obtain an immunomodulating medicine for inhibiting the activity of killer cells, in particular NK cells and/or for inhibiting the primary allogenic response, in pathologies or situations in which the killer cells are activated or for preparing a medicine to raise the inhibiting function of the isoform(s) expressed by said cells with respect to killer cells, in particular NK cells, in pathologies where these killer cells are inhibited by the molecule of the major histocompatibility complex of I HLA-G classes. The invention also concerns eukaryotic cells expressing at their surface at least an HLA-G isoform and their applications. The invention further concerns transgenic animals specifically expressing at least an HLA-G isoform.
Utilisation d'une cellule eucaryote codant au moins une isoforme d'HLA-G, pour l'obtention d'un médicament immunomodulant, destiné à inhiber l'activité des cellules tueuses, notamment des cellules NK et/ou à inhiber la réponse allogénique primaire, dans les pathologies ou les situations dans lesquelles lesdites cellules tueuses sont activées ou d'un médicament destiné à lever la fonction inhibitrice de la ou des isoforme(s) exprimée(s) par lesdites cellules vis-à-vis des cellules tueuses, notamment les cellules NK, dans les pathologies où ces cellules tueuses sont inhibées par la molécule du complexe majeur d'histocompatibilité de classes I HLA-G. Cellules eucaryotes exprimant à leur surface au moins une isoforme d'HLA-G et leurs applications. Animaux transgéniques exprimant de manière spécifique au moins une isoforme d'HLA-G.
Carosella Edgardo Delfino
Dausset Jean
Kirszenbaum Marek
Paul Pascale
Rouas-Freiss Nathalie
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