Eukaryotic fusion proteins, containing interleukin-2 sequences

Details Eukaryotic fusion proteins, containing interleukin-2 sequences Eukaryotic fusion proteins, containing interleukin-2 sequences

C - Chemistry, Metallurgy

12

N

530/13, 195/1.22

C12N 15/62 (2006.01) C07K 14/47 (2006.01) C07K 14/55 (2006.01) C07K 14/62 (2006.01) C07K 14/815 (2006.01) C07K 19/00 (2006.01) C12N 15/12 (2006.01) C12N 15/26 (2006.01) C12N 15/63 (2006.01) C12P 21/02 (2006.01)

Patent

CA 1341203

An "open reading frame" composed of the DNA which codes for interleukin-2 (IL-2) is suitable for the preparation of fusion proteins. A part-sequence of the DNA which approximately corresponds to the first 100 amino acids of IL-2 is adequate for this purpose. The gene for the desired protein can be placed upstream or downstream of the open reading frame. Fusion proteins which are sparingly soluble or insoluble are obtained and can readily be separated from the soluble proteins intrinsic to the host.

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