Eukaryotic gene expression cassette and uses thereof

Details Eukaryotic gene expression cassette and uses thereof Eukaryotic gene expression cassette and uses thereof

C - Chemistry, Metallurgy

12

N

C12N 15/86 (2006.01) A61K 39/00 (2006.01) A61K 48/00 (2006.01) C12N 7/01 (2006.01) C12N 15/85 (2006.01) C12N 15/869 (2006.01) C12Q 1/68 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2278326

An expression cassette comprising a herpes simplex virus latency-associated transcript P2 region, a promoter and a heterologous gene operably linked in that order. The expression cassette is incorporated into herpes simplex virus vectors to allow for delivery of heterologous genes to mammalian cells for long-term expression.

L'invention concerne une cassette d'expression comprenant une région de transcrit P2 associé à la latence du virus herpès simplex, un promoteur et un gène hétérologue liés fonctionnellement, dans cet ordre. On incorpore la cassette d'expression dans des vecteurs du virus herpès simplex pour permettre l'apport de gènes hétérologues dans des cellules mammaliennes pour une expression à long terme.

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