Eukaryotic genes for modulating cell cycle progression

Details Eukaryotic genes for modulating cell cycle progression Eukaryotic genes for modulating cell cycle progression

C - Chemistry, Metallurgy

07

K

C07K 14/435 (2006.01) A61K 31/7088 (2006.01) A61K 38/16 (2006.01) A61K 38/17 (2006.01) A61K 39/395 (2006.01) A61K 48/00 (2006.01) C07K 14/395 (2006.01) C07K 14/47 (2006.01) C12N 15/11 (2006.01) C12N 15/12 (2006.01) C12N 15/31 (2006.01) C12Q 1/68 (2006.01) G01N 33/50 (2006.01) G01N 33/53 (2006.01)

Patent

CA 2538442

The present invention relates to the significant functional role of several C. elegans genes and of their corresponding gene products in cell cycle progression during cell division that could be identified by means of RNA- mediated interference (RNAi) and to the identification and isolation of functional orthologs of said genes including all biologically functional derivatives thereof. The invention further relates to the use of said genes and gene products (including said orthologs) in the development or isolation of anti-proliferative agents, particularly their use in appropriate screening assays, and their use for diagnosis and treatment of proliferative and other diseases. In particular, the invention relates to the use of small interfering RNAs derived from said genes for the treatment of proliferative diseases.

La présente invention concerne le rôle fonctionnel considérable joué par plusieurs gènes chez C. elegans et par leurs produits géniques respectifs dans l'évolution d'un cycle cellulaire au cours de la division cellulaire, qui pourrait être identifié au moyen d'un ARN d'interférence (ARNi). Elle concerne également l'identification et l'isolement d'orthologues fonctionnels desdits gènes, y compris tous leurs dérivés biologiquement fonctionnels. L'invention concerne aussi l'utilisation de ces gènes et produits géniques (y compris lesdits orthologues) dans la mise au point ou l'isolement d'agents antiprolifératifs, en particulier leur utilisation dans des dosages de criblage appropriés, et leur utilisation pour le diagnostic et le traitement de maladies à évolution chronique ou autres. L'invention concerne en particulier l'utilisation de petits ARN interférants, issus de ces gènes, destinés au traitement de maladies à évolution chronique.

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