Eukaryotic initiation factor 5a (eif-5a) mutants

Details Eukaryotic initiation factor 5a (eif-5a) mutants Eukaryotic initiation factor 5a (eif-5a) mutants

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 31/70 (2006.01) A61K 38/17 (2006.01) A61K 48/00 (2006.01) C07K 14/47 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2210538

eIF-5A mutant proteins which are normally devoid of substantial eIF-5A activity and which inhibit Rev function and thus possess an inhibitory phenotype with respect to Rev function, and genes or DNA or cDNA sequences coding therefor.

La présente invention concerne des protéines mutantes d'eIF-5A (facteur d'initiation eucaryote 5A) qui sont normalement dépourvues d'une activité eIF-5A importante et qui inhibent la fonction Rev et possèdent de ce fait un phénotype inhibiteur relativement à la fonction Rev. Elle concerne également des gènes ou des séquences d'ADN ou d'ADN complémentaire codant pour ces protéines.

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