Eva-based transdermal matrix system for the administration...

Details Eva-based transdermal matrix system for the administration... Eva-based transdermal matrix system for the administration...

A - Human Necessities

61

K

A61K 9/70 (2006.01) A61K 31/56 (2006.01)

Patent

CA 2145579

The present invention relates to a new self-adhesive transdermal matrix system for the administration of a hormone by percutaneous route, said system which comprises a support and self- adhesive matrix, having a matrix comprising: (a) 40 to 60 parts by weight of an ethylene/vinyl acetate copolymer, (b) 5 to 20 parts by weight of a cellulosic material, (c) 35 to 55 parts by weight of at least one compound selected from the group consisting of: - crotamiton, - N-substituted 2-pyrrolidones of the formula I, Image (I) in which the R group represents a (C1-C15)-alkyl, cyclohexyl or 2-hydroxyethyl group, and - higher C12-C20 aliphatic alcohols, and (d) 0,01 to 7 parts by weight of a hormone selected from the group consisting of oestrogen components, progestogen components and mixtures thereof. It also relates to a method for preparing this transdermal matrix system.

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