C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 5/10 (2006.01) C07H 21/04 (2006.01) C07K 14/47 (2006.01) C12N 5/00 (2006.01) C12N 15/64 (2006.01) C12Q 1/68 (2006.01) A61K 48/00 (2006.01) A01N 43/04 (2006.01)
Patent
CA 2297328
The invention provides methods of evaluating a tratement for a heart disorder. The invention also provides methods of delivering a compound to the heart of a subject. A heart cell, into which has been introduced by somatic gene transfer, a nucleic acid which results in the expression of phospholamban, a heart tissue, into which has been introduced by somatic gene transfer, a nucleic acid which results in the expression of phospholamban and a heart, into which has been introduced by somatic gene transfer, a nucleic acid which results in the expression of phospholamban are also provided by the invention. Finally, the invention provides a method for treating a subject at risk for a heart disorder.
Cette invention se rapporte à des procédés d'évaluation d'agents adaptés au traitement de cardiopathies, ainsi qu'à des procédés d'administration d'un composé au coeur d'un patient. Cette invention se rapporte à une cellule cardiaque dans laquelle a été introduit, par transfert génique somatique, un acide nucléique qui entraîne l'expression de phospholambane, à un tissu cardiaque dans lequel a été introduit, par transfert génique somatique, un acide nucléique qui entraîne l'expression de phospholambane, et à un coeur dans lequel a été introduit, par transfert génique somatique, un acide nucléique qui entraîne l'expression de phospholambane. L'invention se rapporte enfin à un procédé de traitement d'un sujet à risque vis à vis des cardiopathies.
Guerrero Luis
Hajjar Roger J.
Rosenzweig Anthony
Smart & Biggar
The General Hospital Corporation
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