G - Physics – 01 – N
Patent
G - Physics
01
N
150/9
G01N 33/74 (2006.01) A61K 31/40 (2006.01) A61K 31/495 (2006.01) G01N 33/50 (2006.01) G01N 33/53 (2006.01) G01N 33/564 (2006.01)
Patent
CA 2004133
ABSTRACT Inbred Lewis (LEW/N) female rats develop an arthritis in response to Group A streptococcal cell wall peptidoglycan- polysaccharide (SCW) which mimics human rheumatoid arthritis. Histocompatible Fischer (F344/N) rats, on the other hand, do not develop arthritis in response to the same SCW stimulus. To evaluate this difference in inflammatory reactivity between the two strains, the function of the hypothalamic-pituitary-adrenal axis and its ability to modulate the development of the inflammatory response was studied. It has been found that, in contrast to F344/N rats, LEW/N rats had markedly impaired plasma ACTH and corticosterone responses to SCW, recombinant human Interleukin-1 alpha (IL-l alpha), the serotonin agonist, quipazine, and synthetic rat corticotropin-releasing hormone (CRH). In addition, LEW/N rats compared to F344/N rats had smaller adrenal glands and larger thymuses. Treatment of LEW/N rats with replacement doses of dexamethasone decreased the severity of their SCW-induced arthritis. Conversely, treatment of F344/N rats with the glucocorticoid receptor antagonist, RU 486, or the serotonin (5- HT2) antagonist, LY53857, was associated with development of severe inflammatory disease, including arthritis, in response to SCW. These findings support the concept that susceptibility of LEW/N rats to SCW arthritis is related to abnormal hypothalamic- pituitary adrenal (HPA) axis responsiveness to inflammatory and other stress mediators and that resistance of F344/N rats to SCW arthritis is regulated by an intact HPA axis-immune system feedback loop.
Chrousos George P.
Gold Philip W.
Sternberg Esther M.
Wilder Ronald L.
Chrousos George P.
Gold Philip W.
Gowling Lafleur Henderson Llp
Sternberg Esther M.
United States Of America Represented By The Secretary U.s. Department Of Commerce (the)
LandOfFree
Evaluative means for detecting inflammatory reactivity does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Evaluative means for detecting inflammatory reactivity, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Evaluative means for detecting inflammatory reactivity will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1637894