C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/52 (2006.01) C12P 1/00 (2006.01) C12P 19/62 (2006.01) H01J 49/04 (2006.01)
Patent
CA 2380948
This invention provides libraries of recombinant derivatizing enzymes that are useful for biocatalytic synthesis of derivatives oforganic molecules, including lead compounds for pharmaceutical use. The recombinant derivatizing enzymes catalyze reactions such as modification or replacement of functional groups on the organicmolecules, or addition of chemical moieties onto preexisting functional groups. The use of recombinant enzyme libraries enables one to obtain enzymes that catalyze the formation of organic molecule derivatives that could not otherwise be made using only naturally occurring enzymes.
La présente invention concerne des bibliothèques d'enzymes de dérivatisation recombinées qui conviennent pour la synthèse biocatalytique de dérivés de molécules organiques, notamment des composés de plomb destinés à un usage pharmaceutique. Ces enzymes de dérivatisation recombinées catalysent des réactions telles que la modification ou le remplacement de groupes fonctionnels dans des molécules organiques, ou l'addition de fragments chimiques dans des groupes fonctionnels préexistants. L'utilisation de bibliothèque d'enzymes recombinées permet d'obtenir des enzymes qui catalysent la formation de dérivés de molécules organiques qui autrement ne pourrait être obtenus par les seules enzymes formées naturellement.
Davis S. Christopher
Delcardayre Stephen
Howard Russell
Krebber Claus
Liu Lu
Fetherstonhaugh & Co.
Maxygen Inc.
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