Ex vivo effector cell activation for target cell killing

Details Ex vivo effector cell activation for target cell killing Ex vivo effector cell activation for target cell killing

C - Chemistry, Metallurgy

12

N

167/114, 195/46,

C12N 5/08 (2006.01) A61K 35/18 (2006.01) A61K 39/44 (2006.01) A61K 47/48 (2006.01)

Patent

CA 1302324

ABSTRACT A method and composition for killing target cells is disclosed. The method utilizes ex vivo IL-2 activation of leucocyte effector cells and arming the activated leucocyte effectors with monoclonal antibodies whose Fc portions bind to the IL-2-activated effectors and whose paratopic portions immunoreact with an epitope expressed on the surfaces of the target cells. The composition contains a cytolytic amount of the armed, IL-2-activated effector cells dispersed in an aqueous physiologically tolerable diluent medium. 6412M, D-36S

548671

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