G - Physics – 01 – N
Patent
G - Physics
01
N
G01N 33/567 (2006.01) G01N 15/10 (2006.01) G01N 33/574 (2006.01) G01N 21/64 (2006.01)
Patent
CA 2668197
The invention relates to a method for diagnosing a disease state mediated by pathogenic cells. The method comprises the steps of combining with an ex vivo patient sample a composition comprising a conjugate or complex of the general formula (I) Ab-X wherein the group Ab comprises a ligand that binds to the pathogenic cells and the group X comprises an imaging agent, and detecting the pathogenic cells that express a receptor for the ligand using flow cytometry.
La présente invention concerne un procédé permettant de diagnostiquer un état pathologique médié par des cellules pathogènes. Le procédé comporte les étapes qui consistent à combiner un échantillon ex vivo de patient avec une composition contenant un conjugué ou un complexe de formule générale (I) Ab-X, le groupe Ab comportant un ligand qui se lie aux cellules pathogènes et le groupe X comportant un agent d'imagerie, et à détecter les cellules pathogènes qui expriment un récepteur du ligand à l'aide d'une cytométrie en flux.
He Wei
Kularatne Sumith A.
Low Philip S.
Purdue Research Foundation
Smart & Biggar
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