Excipients in drug delivery vehicles

A - Human Necessities – 61 – K

Patent

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Details

A61K 9/14 (2006.01) A61F 13/00 (2006.01)

Patent

CA 2545913

Injectable depot gel compositions and kits that provide an excipient for modulating a release rate and stabilizing beneficial agents are provided. Methods of administering and preparing such systems are also provided. The gel compositions comprise biodegradable, bioerodible polymers and water-immiscible solvents in amounts effective to plasticize the polymers and form gels with the polymers. Suitable excipients include pH modifiers, reducing agents, and antioxidants.

L'invention concerne des compositions de gel retard injectable et des trousses comprenant un excipient qui permet de moduler la vitesse de libération des agents traitants et de les stabiliser. L'invention concerne également de méthodes d'administration et de préparation de ces systèmes. Ces compositions de gel contiennent des polymères biodégradables et bio-érodables et des solvants non miscibles à l'eau en doses suffisantes pour plastifier les polymères et former des gels avec ces derniers. Les excipients adéquats comprennent des régulateurs de pH, des agents réducteurs, et des anti-oxydants.

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