Excipients in drug delivery vehicles

Details Excipients in drug delivery vehicles Excipients in drug delivery vehicles

A - Human Necessities

61

K

A61K 38/27 (2006.01) A61K 47/30 (2006.01)

Patent

CA 2545923

Injectable depot gel compositions and kits that provide an excipient for modulating a release rate and stabilizing beneficial agents are provided. Methods of administering and preparing such systems are also provided. The gel compositions comprise biodegradable, bioerodible polymers and water-immiscible solvents in amounts effective to plasticize the polymers and form gels with the polymers. Suitable excipients include pH modifiers, reducing agents, and antioxidants.

L'invention concerne des compositions de gel retard injectables et des kits fournissant un excipient qui permettent de moduler une vitesse de libération et de stabiliser des agents bénéfiques. L'invention concerne également l'administration et la préparation de ces systèmes. Les compositions de gel comprennent des polymères biodégradables et bioérodables et des solvants non miscibles dans l'eau en quantité efficace pour plastifier les polymères et les gels avec lesdits polymères. Les excipients appropriés comprennent des modificateurs de pH, des agents de réduction et des antioxydants.

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