C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A61K 38/17 (2006.01) A61K 48/00 (2006.01) C07K 14/705 (2006.01) C07K 16/28 (2006.01) C12N 15/63 (2006.01) C12P 21/02 (2006.01) C12Q 1/02 (2006.01) C12Q 1/68 (2006.01) G01N 33/566 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2457288
The invention provides isolated N-methyl-D- aspartate type 3B (NR3B) polypeptides, functional fragments and peptides, encoding nucleic acid molecules and polynucleotides, and specific antibodies. Also provided are excitatory glycine receptors, containing either NR3B or NR3A polypeptides. Further provided are methods for detecting excitatory glycine receptor ligands, agonists and antagonists. The invention also provides related diagnostic and therapeutic methods.
L'invention concerne des polypeptides isolés de N-méthyl-D- aspartate de type 3B (NR3B), des fragments fonctionnels et des peptides, des molécules d'acide nucléique de codage et des polynucléotides, ainsi que des anticorps spécifiques. L'invention concerne également des récepteurs excitateurs de la glycine renfermant soit des polypeptides NR3B, soit des polypeptides NR3A, ainsi que des procédés de détection de ligands, d'agonistes et d'antagonistes des récepteurs excitateurs de la glycine,. L'invention concerne enfin des procédés diagnostiques et thérapeutiques associés.
Awobuluyi Marc
Chatterton Jon E.
Lipton Stuart A.
Sevarino Kevin A.
Zhang Dongxian
Brigham And Women's Hospital Inc.
Smart & Biggar
The Burnham Institute
Yale University
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