Exendin 4 polypeptide fragments and use thereof

Details Exendin 4 polypeptide fragments and use thereof Exendin 4 polypeptide fragments and use thereof

C - Chemistry, Metallurgy

07

K

C07K 14/575 (2006.01) A61K 38/22 (2006.01) A61P 3/00 (2006.01) A61P 3/10 (2006.01)

Patent

CA 2613903

Exendin 4 polypeptide fragments having blood sugar lowering action which can be used for treating type II diabetes are provided. The polypeptide fragments have the sequence of HGEGTX1TSDLSKQX2EEEAVX3LFIEWLKNGX4PX5, wherein X1 represents Phe or Tyr, X2 represents Met, Ile or Leu, X3 represents Lys, X4 represents Gly or deletion, and X5 represents Arg or deletion. The process for preparing the Exendin 4 polypeptide fragments is also provided.

Cette invention concerne des fragments polypeptidiques d'exendine 4 ayant une action d'abaissement du taux de sucre dans le sang, qui peuvent servir à traiter le diabète non insulino-dépendant. Ces fragments polypeptidiques possèdent la séquence HGEGTX1TSDLSKQX2EEEAVX3LFIEWLKNGX4PX5, dans laquelle X1 représente Phe ou Tyr, X2 représente Met, Ile ou Leu, X3 représente Lys, X4 représente Gly ou une délétion, et X5 représente Arg ou une délétion. Cette invention concerne également le procédé permettant de préparer ces fragments polypeptidiques d'exendine 4.

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