C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/62 (2006.01) A61K 38/22 (2006.01) A61K 47/48 (2006.01) A61P 3/10 (2006.01) C07K 14/575 (2006.01) C07K 14/605 (2006.01) C07K 14/79 (2006.01) C07K 19/00 (2006.01)
Patent
CA 2658654
The invention provides fusion proteins comprising an exendin-4 fused to a transferrin (Tf) via a polypeptide linker, as well as corresponding nucleic acid molecules, vectors, host cells, and pharmaceutical compositions. The invention also provides the use of the exendin-4/Tf fusion proteins for treatment of Type Il diabetes, obesity, and to reduce body weight.
L'invention concerne des protéines de fusion comprenant une extendine-4 fusionnée à une transferrine (Tf) par un liant à base de polypeptide, ainsi que des molécules d'acide nucléique, des vecteurs, des cellules hôtes et des compositions pharmaceutiques correspondants. L'invention concerne également l'utilisation de protéines de fusion d'extendine-4/Tf dans le traitement du diabète de type Il, de l'obésité, et afin de réduire le poids corporel.
Ballance David James
Prior Christopher Philip
Sadeghi Homayoun
Turner Andrew John
Biorexis Pharmaceutical Corporation
Smart & Biggar
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