C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C12N 5/10 (2006.01) G01N 33/50 (2006.01)
Patent
CA 2317922
The present invention is directed to novel exocytotic polypeptides, such as Exo1 and Exo2 polypeptides and related molecules, which have an inhibitory effect on exocytosis and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided by the present invention are methods for identifying novel compositions which mediate exocytotic polypeptide bioactivity, and the use of such compositions in diagnosis and treatment of disease.
La présente invention concerne de nouveaux polypeptides exocytotiques tels que Exo 1 et Exo 2 et des molécules apparentées, qui ont un effet inhibiteur sur l'exocytose, ainsi que des molécules d'acide nucléique codant pour ces polypeptides. L'invention concerne également des vecteurs et des cellules hôtes renfermant ces séquences nucléotidiques, des molécules de polypeptides chimères renfermant les polypeptides couverts par la présente invention et fixés à des séquences polypeptidiques hétérologues, des anticorps qui se lient aux polypeptides de la présente invention et des procédés de fabrication desdits polypeptides. De plus, l'invention a trait à un procédé qui permet d'identifier de nouvelles compositions ayant une fonction de médiateur dans une bioactivité polypeptidique exocytotique ainsi que l'emploi de ces compositions dans le diagnostic et le traitement de maladies.
Anderson David
Fisher Joseph
Huang Betty
Lorens James
Luo Ying
Rigel Pharmaceuticals Inc.
Smart & Biggar
LandOfFree
Exo1 and exo2, exocytotic proteins does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Exo1 and exo2, exocytotic proteins, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Exo1 and exo2, exocytotic proteins will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1626330