Exocytosis pathway proteins and methods of use

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/12 (2006.01) A61K 38/17 (2006.01) C07K 14/435 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C12N 5/10 (2006.01) C12N 15/10 (2006.01) C12N 15/63 (2006.01) C12Q 1/68 (2006.01) G01N 33/50 (2006.01) G01N 33/566 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2359145

(57) Abstract: The present invention is directed to novel polypeptides such as the Exo protein and related molecules which have an effect on or are related to exocytosis and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided by the present invention are method for identifying novel compositions which mediated Exo bioactivity, and the use of such compositions in diagnosis and treatment of disease.

La présente invention concerne de nouveaux polypeptides telles que l'exo-protéine et les molécules apparentées ayant une action sur/relative à l'exocytose et aux molécules d'acide nucléique codant ces polypeptides. En outre, cette invention concerne des vecteurs et des cellules hôtes contenant ces séquences d'acide nucléique, des molécules de polypeptides chimériques contenant les polypeptides précités accolés à des séquences polypeptidiques hétérologues, des anticorps se liant à ces polypeptides, ainsi que des procédés de production de ces polypeptides. En outre, cette invention concerne un procédé d'identification de nouvelles compositions permettant l'exo-bioactivité, et l'utilisation de ces compositions dans le diagnostic et le traitement de maladies.

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