Exoenzyme toxin of aeromonas salmonicida, and uses therefor

Details Exoenzyme toxin of aeromonas salmonicida, and uses therefor Exoenzyme toxin of aeromonas salmonicida, and uses therefor

C - Chemistry, Metallurgy

12

N

C12N 15/54 (2006.01) A61K 39/02 (2006.01) A61P 31/04 (2006.01) C07K 14/195 (2006.01) C12N 9/10 (2006.01) C12P 21/02 (2006.01) G01N 33/50 (2006.01) G01N 33/569 (2006.01)

Patent

CA 2467360

A protein toxin named Aeromonas salmonicida exoenzyme T (AexT), which belongs to the family of ADP-ribosylating toxins, is disclosed as is a Calcium (or other cation concentration) dependent promoter of A. salmonicida. Also disclosed are diagnostic, preventive, and therapeutic techniques, including the preparation of bacterin vaccines based on AexT for inducing immunity against A. salmonicida infections.

L'invention concerne une toxine protéique, dénommée exoenzyme T d'Aeromonas salmonicida (AexT), appartenant à la famille des toxines ADP-ribosylantes, ainsi qu'un promoteur à dépendance calcique (ou de la concentration d'un autre cation) d'A. salmonicida. Elle concerne aussi des techniques de diagnostic, de soins et de prévention, y comprise la préparation de vaccins traditionnel, recombinant et bactérien amélioré, basés sur AexT afin d'induire une immunité contre des infections par A. salmonicida.

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