A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 47/42 (2006.01) A61K 47/48 (2006.01) A61P 3/10 (2006.01) C08J 3/24 (2006.01) C08L 89/00 (2006.01)
Patent
CA 2750223
The disclosure provides cross-linked materials that include multiva-lent cross-linking agents that bind an ex-ogenous target molecule; and conjugates that include two or more separate affinity ligands bound to a conjugate framework, wherein the two or more affinity ligands compete with the exogenous target molecule for binding with the cross-linking agents and wherein conjugates are cross--linked within the material as a result of non-covalent interactions between cross--linking agents and affinity ligands on dif-ferent conjugates. The conjugates also in-clude a drug.
La présente invention concerne des matériaux réticulés comportant des agents de réticulation multivalents se liant à une molécule cible exogène; et des conjugués comportant au moins deux ligands d'affinité séparés liés à une structure conjuguée, lesdits deux ligands d'affinité ou davantage entrant en concurrence avec la molécule cible exogène en matière de liaison avec les agents de réticulation et lesdits conjugués étant réticulés au sein du matériau suite à des interactions non covalentes entre les agents de réticulation et les ligands d'affinité sur différents conjugués. Lesdits conjugués incluent également un médicament.
Lancaster Thomas M.
Zion Todd C.
Gowling Lafleur Henderson Llp
Smartcells Inc.
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