Exonuclease-resistant oligonucleotides and methods for...

Details Exonuclease-resistant oligonucleotides and methods for... Exonuclease-resistant oligonucleotides and methods for...

C - Chemistry, Metallurgy

07

H

C07H 21/00 (2006.01)

Patent

CA 2058632

A method is provided for making 3' and/or 5' end-capped oligonucleotides so as to render the oligonucleotide resistant to degradation by exonucleases. The exonuclease degradation resistance is provided by incorporating two or more phosphoramidate and phosphoromonothioate and/or phosphorodithioate linkages at the 5' and/or 3' ends of the oligonucleotide, wherein the number of phosphoramidate linkages is less than a number which would interfere with hybridization to a complementary oligon- ucleotide strand and/or which would interfere with RNAseH activity when the oligonucleotide is hybridized to RNA.

Affiliated with

Also associated with

Rating

Exonuclease-resistant oligonucleotides and methods for... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Exonuclease-resistant oligonucleotides and methods for..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Exonuclease-resistant oligonucleotides and methods for... will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1694239