A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 9/00 (2006.01) A61D 7/00 (2006.01) A61K 9/48 (2006.01) A61M 31/00 (2006.01)
Patent
CA 2277277
The present invention describes a device for the controlled release of active compounds in the gastrointestinal tract with delayed pyloric passage, having a component expandable on contact with gastric juice, which is surrounded by a polymer covering which is permeable to gastric juice and active compounds. The device contains at least one active compound which is present in a multiparticulate preparation which releases the active compound into the gastric juice with a delay. Compared with conventional pharmaceutical forms with delayed pyloric passage, the release of active compound from a device according to the invention can be better controlled; likewise the device can be easily rolled or folded and can be introduced into capsules without problems.
L'invention concerne un dispositif de libération contrôlée de principes actifs dans le tractus gastro-intestinal à passage différé à travers le pylore, comprenant des constituants pouvant s'expanser au contact du suc gastrique et étant entourés d'une enveloppe polymère perméable au suc gastrique et aux principes actifs. Ce dispositif contient au moins un principe actif se trouvant dans une préparation multiparticulaire, qui libère le principe actif de manière retardée dans le suc gastrique. Comparativement aux formes galéniques médicamenteuses classiques à passage à travers le pylore, la libération de principes actifs effectuée à l'aide d'un dispositif de ce type est plus facile à piloter. De plus, le dispositif est facile à enrouler ou à plier et peut de ce fait est aisément introduit dans des capsules.
Asmussen Bodo
Cremer Karsten
Hoffmann Hans-Rainer
Ludwig Karin
Roreger Michael
Blake Cassels & Graydon Llp
Lts Lohmann Therapie-Systeme Ag
Lts Lohmann Therapie-Systeme Gmbh
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