Expandable medical device for delivery of beneficial agent

A - Human Necessities – 61 – F

Patent

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Details

A61F 2/06 (2006.01) A61L 31/14 (2006.01) A61L 31/16 (2006.01) A61F 2/00 (2006.01)

Patent

CA 2457129

An expandable medical device has a plurality of elongated struts joined together to form a substantially cylindrical device which is expandable from a cylinder having a first diameter to a cylinder having a second diameter. At least one of the plurality of struts includes at least one opening extending at least partially through a thickness of said strut. A beneficial agent is loaded into the opening within the strut in layers to achieve desired temporal release kinetics of the agent. Alternatively, the beneficial agent is loaded in a shape which is configured to achieve the desired agent delivery profile. A wide variety of delivery profiles can be achieved including zero order, pulsatile, increasing, decrease, sinusoidal, and other delivery profiles.

Un dispositif médical extensible comprend plusieurs entretoises allongées réunies entre elles de manière à former un dispositif sensiblement cylindrique extensible de façon à transformer un cylindre possédant un premier diamètre en un cylindre possédant un deuxième diamètre. Au moins une des entretoises comprend au moins une ouverture qui s'étend au moins partiellement à travers l'épaisseur de ladite entretoise. Un agent utile est chargé par couches dans l'ouverture à l'intérieur de l'entretoise de manière à assurer une cinétique temporelle désirée de l'agent. En variante, l'agent utile est chargé dans une forme qui est configurée pour obtenir un profil désiré d'apport de l'agent. On peut ainsi obtenir une large gamme de profils d'apport, y compris les profils d'ordre zéro, par impulsions, croissant, décroissant, sinusoïdal et autres.

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