C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 487/22 (2006.01) A61K 39/395 (2006.01) A61K 41/00 (2006.01)
Patent
CA 2047699
The present invention involves a novel tripyrroledimethine-derived "expanded porphyrin" (texaphyrin), the synthesis of such compounds, their analogs or derivatives and their uses. These expanded porphyrin-like macrocycles are efficient chelators of divalent an trivalent metal ions. Metal complexes of these compounds are active as photosensitizers for the generation of singlet oxygen and thus potentially for inactivation or destruction of human immunodeficiency virus (HIV-1), mononuclear or other cells infected with such virus and tumor cells as well. A variety of texaphyrin derivatives have been produced and many more are readily obtainable. Various metal (e.g., transition, main group, and lanthanide) complexes with the texaphyrin and texaphyrin derivatives of the present invention have unusual water solubility and stability which render them particularly useful. These metallotexaphyrin complexes have optical properties making them unique as compared to existing porphyrin-like or other macrocycles. For example, they absorb light strongly in a physiologically important region (i.e. 690-880 nm). These complexes also form long-lived triplet states in high yield and act as efficient photosensitizers for the formation of singlet oxygen. These properties, coupled with their high chemical stability and appreciable solubility in polar media such as water add to their usefulness.
Hemmi Gregory W.
Murai Toshiaki
Sessler Jonathan L.
Blake Cassels & Graydon Llp
Board Of Regents The University Of Texas System
The Board Of Regents Of The University Of Texas
LandOfFree
Expanded porphyrins: large prophyrin-like... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Expanded porphyrins: large prophyrin-like..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Expanded porphyrins: large prophyrin-like... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1475315