C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 5/08 (2006.01) A61K 35/28 (2006.01) A61K 38/17 (2006.01) C07K 16/22 (2006.01) C12N 5/02 (2006.01) C12N 5/06 (2006.01) A61K 35/12 (2006.01)
Patent
CA 2155515
A method for expanding growth of hematopoietic stem cells in culture includes a step of admixing to the culture a TGF-.beta. antagonist such as a soluble TGF-.beta. receptor or a TGF-.beta.-neutralizing antibody. Also, treating an animal includes steps of admixing a TGF-.beta. antagonist to a culture of bone marrow cells to stimulate production of hematopoietic stem cells in the culture, and thereafter administering hematopoietic cells so produced to the animal. Also, a method for treating an animal includes steps of administering a TGF-.beta. antagonist to the animal.
Dasch James
Kincade Paul W.
Waegell Wendy
Celtrix Pharmaceuticals Inc.
Fetherstonhaugh & Co.
Oklahoma Medical Research Foundation
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