Expressed dna sequences involved in mitochondrial functions

Details Expressed dna sequences involved in mitochondrial functions Expressed dna sequences involved in mitochondrial functions

C - Chemistry, Metallurgy

12

N

C12N 15/11 (2006.01) C07H 21/04 (2006.01) C12Q 1/68 (2006.01)

Patent

CA 2356540

This invention provides sets of isolated nucleic acid molecules involved in mitochondrial biology, arrays containing probes for genes involved in mitochondrial biology, methods for making such arrays, and methods of using such arrays. Genes and probe sequences involved in mitochondrial biology in humans and mice are provided. The arrays of this invention are useful for determining mitochondrial biology gene expression profiles. Mitochondrial biology gene expression profiles are useful for determining expression profiles diagnostic of pathological conditions and for diagnosing pathological conditions. This invention provides methods for diagnosing Leigh's disease. Arrays containing probes for all genes known to be involved in mitochondrial biology are provided, as well as arrays containing subsets of such probes.

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