Expression and characterization of hiv-1 envelope protein...

A - Human Necessities – 61 – K

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A61K 48/00 (2006.01) A61K 38/00 (2006.01) C07K 5/00 (2006.01) C07K 14/16 (2006.01) C12P 21/00 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2338886

The present invention relates to HIV-1 envelope proteins that induce the production of broadly cross-reactive neutralizing anti-serum against multiple strains of HIV- 1. The present invention further relates to use of the HIV-1 envelope in vaccine compositions or to generate immune responses.

La présente invention concerne des protéines d'enveloppe VIH-1 provenant d'un donneur atteint d'une infection à VIH-1 non progressive, le sérum de ce donneur contenant des anticorps de neutralisation d'un virus primaire largement réactifs. Cette invention concerne également des protéines isolées ou purifiées ainsi que des fragments protéiques partageant des acides aminés avec lesdites protéines VIH-1 sur certaines positions.

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