C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
195/1.235, 195/1
C12N 15/10 (2006.01) C07K 1/16 (2006.01) C07K 14/16 (2006.01) C12N 1/00 (2006.01) C12N 1/21 (2006.01) C12N 15/66 (2006.01) C12P 21/00 (2006.01) A61K 39/00 (2006.01)
Patent
CA 1341384
Immunologically reactive gag proteins of LAV are expressed in bacterial cells. The gag proteins are encoded by a recombinant plasmid containing procaryotic trancriptional and translational signals for expression, followed downstream by a DNA sequence comprising a portion of the gag region of LAV. Preferred signals for expression are selected from an inducible and/or suppressible operon, such as the trp operon. The gag proteins are isolated from the bacterial host and are utilized in diagnostic assays which detect the presence of LAV antigens or antibodies immunologically reactive with LAV. Further, the proteins produced by the method disclosed may be used as a vaccine against infection by the causative virus for acquired immune deficiency syndrome.
506020
Cosand Wesley
Mcardle Susan
Travis Bruce Mcfarland
Ward Pamela June
Watanabe Susan Mitsue
Bio-Rad Laboratories Inc.
Genetic Systems Corporation
Gowling Lafleur Henderson Llp
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