C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/74 (2006.01) C07K 14/145 (2006.01) C07K 14/195 (2006.01) C07K 14/21 (2006.01) C07K 19/00 (2006.01) C12N 1/21 (2006.01) C12N 15/09 (2006.01) C12N 15/31 (2006.01) C12N 15/47 (2006.01) C12N 15/62 (2006.01)
Patent
CA 2247805
DNA constructs are provided which code for a chimeric protein in which the C- terminal region correponds to the extreme C-terminal amino acids of a Caulobacter S-layer protein, fused with a heterologous polypeptide. Bacterial cells containing, or which express the DNA constructs and secrete the resulting protein are also provided. Chimeric proteins including the C- terminal amino acids of a Caulobacter S-layer protein are provided, including proteins which include antigenic epitopes of the Infectious Hematopoietic Necrosis Virus.
L'invention concerne des produits de recombinaison d'ADN codant pour une protéine chimère dans laquelle la région d'extrémité C-terminale correspond aux acides aminés C-terminaux extrêmes d'une protéine de surface de Colobacter, fusionnée à un polypeptide hétérologue. L'invention concerne également des cellules bactériennes contenant ou exprimant le produit de recombinaison d'ADN et sécrétant la protéine obtenue. L'invention concerne aussi les protéines chimères comprenant les acides aminés C-terminaux d'une protéine de surface de Colobacter ainsi que les protéines comprenant des déterminants antigéniques du virus de la nécrose hématopoiétique infectieuse.
Bingle Wade H.
Nomellini John F.
Smit John
Research Corporation Technologies Inc.
Smart & Biggar
The University Of British Columbia
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