Expression and secretion of mature human beta interleukin-1...

Details Expression and secretion of mature human beta interleukin-1... Expression and secretion of mature human beta interleukin-1...

C - Chemistry, Metallurgy

12

N

195/1.16, 167/10

C12N 15/75 (2006.01) A61K 38/20 (2006.01) A61K 39/39 (2006.01) C07K 14/545 (2006.01) C12N 1/21 (2006.01) C12P 21/02 (2006.01)

Patent

CA 2021406

28 ABSTRACT A new plasmid vector is described which can replicate in B.subtilis and which can express and secrete, in the culture medium, human beta interleukin-1 (beta IL-1) without amino acid sequences extraneous to the natural molecule, a strain of B.subtilis transformed by the vector and a method for the expression and secretion of mature human beta interleukin-l. The human beta interleukin-l thus obtained shows a specific acitvity of 1 x 109 U/mg of protein and is particularly suitable as a stimulant for the immune system, as an adjuvant in vaccines for the activation of the repair mechanism in cases of tissue damage, and for the treatment of auto-immune diseases in man.

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