C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/13 (2006.01) C07K 16/00 (2006.01) C07K 16/24 (2006.01) C12N 1/21 (2006.01) C12N 15/63 (2006.01) C12N 15/72 (2006.01)
Patent
CA 2625144
The present invention provides a dicistronic message for producing an antibody molecule, in which the upstream cistron contains DNA coding for the light chain of the antibody and the downstream cistron contains DNA coding for the corresponding heavy chain, characterised in that the dicistronic message comprises a sequence selected from AEOSl (SEQ ID NO:1), AEOS2 (SEQ ID NO:2), AEOS3 (SEQ ID NO:3), AEOS4 (SEQ ID NO: 4), AEOS5 (SEQ ID NO:5), AEOS6 (SEQ ID NO:6), AEOS7 (SEQ ID NO:7), AEOS8 (SEQ ID NO:8), AEOS9 (SEQ ID NO:9), AEOSlO (SEQ ID NO:10) and AEOSl 1 (SEQ ID NO:11).
La présente invention concerne un message dicistronique pour produire une molécule d'anticorps, dans lequel le cistron amont contient de l'ADN codant pour la chaîne légère de l'anticorps et le cistron aval contient de l'ADN codant pour la chaîne lourde correspondante. L'invention est caractérisée en ce que le message dicistronique comprend une séquence sélectionnée parmi AEOS1 (SEQ ID NO:1), AEOS2 (SEQ ID NO:2), AEOS3 (SEQ ID NO:3), AEOS4 (SEQ ID NO: 4), AEOS5 (SEQ ID NO:5), AEOS6 (SEQ ID NO:6), AEOS7 (SEQ ID NO:7), AEOS8 (SEQ ID NO:8), AEOS9 (SEQ ID NO:9), AEOS1O (SEQ ID NO:10) et AEOS11 (SEQ ID NO:11).
Ellis Mark
Humphreys David Paul
Robic
Ucb Pharma S.a.
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