Expression in e. coli antibody fragments having at least a...

Details Expression in e. coli antibody fragments having at least a... Expression in e. coli antibody fragments having at least a...

C - Chemistry, Metallurgy

12

N

C12N 15/13 (2006.01) C07K 16/00 (2006.01) C07K 16/06 (2006.01) C07K 16/46 (2006.01)

Patent

CA 2116774

Methods for the high yield production of antibody Fv-containing polypeptides, especially Fab' and F(ab')2 antibody frag- ments are provided. Expression of heavy and light chain Fv in a microbial secretory system is followed by recovery of Fv from the periplasm under conditions that maintain a cysteine residue as a free thiol. The free thiol is reacted with free thiol of an antibody fragment of the same or differing specificity, or with agents such as diagnostic labels or therapeutic moieties. The products offer advantages of homogeneity and purity not available through the use of known methods for preparing such derivatives:

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