C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/86 (2006.01) C12N 5/10 (2006.01) C12N 15/861 (2006.01)
Patent
CA 2113464
The use of human cell lines for producing heterologous proteins, particularly therapeutically useful proteins, on an industrial scale after genetic engineering of their coding sequence and insertion into a suitable vector, is disclosed. The cell lines are non-tumoral lymphoblastoid lines which have been immortalized by EBV. The construction of an integrative-type vector plasmid comprising an expression cassette designed to promote the optimal expression of heterologous DNA sequences in lymphoblastoid cells is also disclosed.
2113464 9303163 PCTABS00161 L'invention concerne l'utilisation de lignées cellulaires humaines pour la production, à l'échelle industrielle, de protéines hétérologues, plus particulièrement d'intérêt thérapeutique, après manipulation génétique de leur séquence codante et insertion dans un vecteur approprié. Les lignées cellulaires sont des lignées lymphoblastoïdes non tumorales immortalisées par l'EBV. L'invention concerne également la construction du plasmide vecteur de type intégratif comportant une cassette d'expression conçue pour favoriser l'expression optimale de séquences d'ADN hétérologue dans les cellules lymphoblastoïdes.
Ballay Annick
Boffa Georges
Cartron Jean-Pierre
Chretien Stany
Lambin Patrick
Fondation Nationale de Transfusion Sanguine
Robic
LandOfFree
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