Expression in plants of antibodies against enterotoxigenic...

C - Chemistry – Metallurgy – 12 – N

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C12N 15/82 (2006.01) C07K 14/415 (2006.01) C07K 16/12 (2006.01)

Patent

CA 2516286

The present invention relates to the expression of antibodies and/or fragments thereof in plants, and in particular to the expression of antibodies and/or fragments thereof that have specificity for enterotoxigenic Escherichia coli. Nucleotide and amino acid sequences of such antibodies and/or fragments are disclosed, as are methods of producing such antibodies and /or fragments, transgenic plants expressing such antibodies and/or fragments thereof, and methods of using such transgenic plants or material derived therefrom, in particular in the treatment or prevention of enteric disease. Also described are methods of enhancing the stability antibodies and fragments thereof.

La présente invention a trait à l'expression d'anticorps et/ou de fragments de ceux-ci dans des plantes, et notamment à l'expression d'anticorps et/ou des fragments de ceux-ci présentant une spécificité pour l'Escherichia coli entéro-toxigène. L'invention a également trait à des séquences nucléotidiques et d'acides aminés de tels anticorps et/ou fragments, des plantes transgéniques exprimant de tels anticorps et/ou des fragments de ceux-ci, ainsi que des procédés d'utilisation de ces plantes transgéniques ou de substance dérivée de celles-ci, notamment dans le traitement ou la prévention de maladie intestinale. L'invention a trait en outre à des procédés d'amélioration de la stabilité des anticorps et/ou des fragments de ceux-ci.

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