Expression of a human insulin precursor in p. pastoris

Details Expression of a human insulin precursor in p. pastoris Expression of a human insulin precursor in p. pastoris

C - Chemistry, Metallurgy

12

N

C12N 1/19 (2006.01) C12N 15/81 (2006.01) C12P 21/02 (2006.01) C07K 14/62 (2006.01) C12N 15/17 (2006.01)

Patent

CA 2357072

Methylotrophic recombinant yeast strain producing human insulin precursor, the strain comprising, in its genome, a copy of a first DNA construction and a second DNA construction, wherein the construction are capably of directing the expression and secretion of human insulin precursor of the formula B(1-30)-Y1-Y2-A (1-21), wherein Y1 is lysine or arginine; Y2 is lysine or arginine; B(1-30) is the B peptide of the human insulin; and B(1-21) is the A peptide of human insulin, and wherein the strain is yeast Pichia Pastoris. DNA constructions and method for obtaining the strain are also provided.

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