Expression of active human protein c in mammary tissue of...

C - Chemistry – Metallurgy – 12 – N

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C12N 15/57 (2006.01) A01K 67/027 (2006.01) C12N 5/10 (2006.01) C12N 9/64 (2006.01) C12N 15/85 (2006.01) C12N 15/89 (2006.01)

Patent

CA 2099562

Recombinant protein C characterized by a high percentage of active protein can be obtained in the milk of transgenic animals that incorporate DNAs according to the present invention. Transgenic animals of the present invention are produced by introducing into developing embryos DNA that encodes protein C, such that the DNA is stably incorporated in the DNA of germ line cells of the mature animal and inherited in normal, mendelian fashion.

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