Expression of biologically active polypeptides in duckweed

Details Expression of biologically active polypeptides in duckweed Expression of biologically active polypeptides in duckweed

C - Chemistry, Metallurgy

12

N

C12N 15/82 (2006.01) C07K 14/56 (2006.01) C12N 15/62 (2006.01) C12N 15/67 (2006.01)

Patent

CA 2417415

Methods, nucleic acid sequences, and transformed duckweed plant or duckweed nodule cultures for the expression and the secretion of biologically active polypeptides from genetically engineered duckweed are provided. Expression of recombinant polypeptides in duckweed is improved by modifying the nucleotide sequence of the expression cassette encoding the polypeptide for improved expression in duckweed. Recovery of biologically active polypeptides from duckweed is improved by linking the biologically active polypeptide to a signal peptide that directs the secretion of the polypeptide into the culture medium.

L'invention concerne des méthodes, des séquences d'acide nucléique, et une lenticule mineure ou des cultures de nodules de lenticule mineure destinées à l'expression et à la sécrétion de polypeptides biologiquement actifs à partir d'une lenticule mineure génétiquement modifiée. L'expression de polypeptides recombinants dans une lenticule mineure est améliorée par modification de la séquence nucléotidique de la cassette d'expression codant le polypeptide pour une expression améliorée dans la lenticule mineure. La récupération d'un polypeptide biologiquement actif à partir d'une lenticule mineure est améliorée par liaison dudit polypeptide à un peptide signal qui oriente la sécrétion du polypeptide dans le milieu de culture.

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