Expression of class 2 mannosidase and class iii mannosidase...

Details Expression of class 2 mannosidase and class iii mannosidase... Expression of class 2 mannosidase and class iii mannosidase...

C - Chemistry, Metallurgy

12

N

C12N 15/62 (2006.01) C07K 19/00 (2006.01) C12N 1/15 (2006.01) C12N 1/19 (2006.01) C12N 5/10 (2006.01) C12N 9/10 (2006.01) C12N 9/24 (2006.01) C12N 15/12 (2006.01) C12N 15/56 (2006.01) C12N 15/81 (2006.01) C12P 19/14 (2006.01) C12P 21/00 (2006.01) C40B 40/08 (2006.01)

Patent

CA 2516544

A method for producing human-like glycoproteins by expressing a Class 2 .alpha.-mannosidase having a substrate specificity for Man.alpha.l,3 and Man.alpha.l,6 glycosidic linkages in a lower eukaryote is disclosed. Hydrolysis of these linkages on oligosaccharides produces substrates for further N-glycan processing in the secretory pathway.

L'invention concerne une méthode de production de glycoprotéines de type humain, consistant à exprimer une .alpha.-mannosidase de classe 2 présentant une spécificité de substrat pour des liaisons glycosidiques Man.alpha.1,3 et Man.alpha.1,6, dans un eukaryote inférieur. L'hydrolyse de ces liaisons sur des oligosaccharides produit des substrats pour un traitement de N-glycane plus avancé dans la voie de sécrétion.

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