Expression of factor vii and ix activities in mammalian cells

Details Expression of factor vii and ix activities in mammalian cells Expression of factor vii and ix activities in mammalian cells

C - Chemistry, Metallurgy

12

N

195/1.2, 195/1.3

C12N 15/57 (2006.01) C07K 14/755 (2006.01) C12N 9/64 (2006.01) C12N 15/62 (2006.01) A61K 38/00 (2006.01)

Patent

CA 1340512

Methods are disclosed for producing proteins having biological activity for blood coagulation mediated by Factor VIIa or Factor IX. The proteins are produced by mammalian host cells which have been stably transfected with a DNA construct containing a nucleotide sequence which codes at least partially for either Factor VII or Factor IX. The nucleotide sequence comprises a first nucleotide sequence encoding a calcium binding domain, joined to a second nucleotide sequence positionned downstream of the first sequence. In particular, the first nucleotide sequence may be derived from a genomic clone or cDNA clone of Factor VII. The second sequence encodes a catalytic domain for the serine protease activity of either Factor VIIA or Factor IX. The joined sequences code for proteins having substantially the same biological activity for blood coagulation as either Factor VIIa or Factor IX.

506908

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