Expression of functional vertebrate phospholipases in yeast

Details Expression of functional vertebrate phospholipases in yeast Expression of functional vertebrate phospholipases in yeast

C - Chemistry, Metallurgy

12

N

C12N 15/55 (2006.01) C07K 14/47 (2006.01) C07K 14/705 (2006.01) C07K 14/72 (2006.01) C12N 1/19 (2006.01) C12N 9/16 (2006.01) C12N 15/12 (2006.01) C12Q 1/02 (2006.01) C12Q 1/44 (2006.01) C12Q 1/68 (2006.01)

Patent

CA 2220459

Yeast cells comprising a heterologous phospholipase C protein and methods for their use in drug screening assays to identify a modulator (i.e. agonist or antagonist) of a phospholipase C are described.

L'invention se rapporte à des cellules de levure comprenant une protéine de phospholipase C hétérologue et à leurs procédés d'utilisation dans des méthodes de criblage de médicaments permettant d'identifier un modulateur (c'est-à-dire un agoniste ou un antagoniste) d'une phospholipase C.

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