Expression of human proapolipoprotein a-i

Details Expression of human proapolipoprotein a-i Expression of human proapolipoprotein a-i

C - Chemistry, Metallurgy

12

N

195/1.2, 195/1.2

C12N 15/12 (2006.01) C07K 14/775 (2006.01) C12N 1/21 (2006.01) C12N 5/10 (2006.01) C12N 15/70 (2006.01) C12N 15/85 (2006.01) A61K 38/00 (2006.01)

Patent

CA 1323851

A B S T R A C T The present invention provides recombinant DNA sequences comprising a sequence which codes for human proapolipoprotein A-I wherein part of the natural coding sequence has been replaced by a DNA fragment coding for the same amino acids but consisting of a different nucleotide sequence such as to reduce or prevent formation of hairpins, cloning and expression vectors containing these DNA sequences, cell cultures or microorganisms transformed with these expression vectors and processes using the same for the production of proapolipoprotein A-I.

566894

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