Expression of malaria polypeptides

Details Expression of malaria polypeptides Expression of malaria polypeptides

C - Chemistry, Metallurgy

12

N

C12N 15/62 (2006.01) A61K 39/015 (2006.01) A61K 39/39 (2006.01) C07K 14/00 (2006.01) C07K 14/445 (2006.01) C07K 14/57 (2006.01) C07K 19/00 (2006.01) C12N 1/19 (2006.01) C12N 15/23 (2006.01) C12N 15/30 (2006.01) C12N 15/57 (2006.01) C12N 15/67 (2006.01) G01N 33/569 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2095540

2095540 9208795 PCTABS00013 The present invention is directed to recombinant expression of malaria polypeptides. Nucleic acid constructs having a domain encoding a malaria polypeptide, preferably SERA or an epitope-containing fragment thereof, downstream from a domain encoding a ubiquitin polypeptide are presented. Additionally, constructs with a third domain encoding an immunomodulator polypeptide, preferably human .gamma.-interferon, and positioned between the first and second domains encoding, respectively, ubiquitin and a malaria polypeptide are also included. The malaria polypeptides of the present invention have utility as vaccine candidates and in immunodiagnostic applications.

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