Expression of mammalian genes at high levels in host cells

Details Expression of mammalian genes at high levels in host cells Expression of mammalian genes at high levels in host cells

C - Chemistry, Metallurgy

12

N

167/104, 167/202

C12N 15/85 (2006.01) A01K 67/027 (2006.01) A61K 31/70 (2006.01) A61K 35/12 (2006.01) A61K 48/00 (2006.01) C07K 14/705 (2006.01) C07K 14/805 (2006.01) C12N 5/10 (2006.01) C12N 15/90 (2006.01)

Patent

CA 1336269

The present invention relates in particular to vectors for the integration of a gene into the genetic material of a mammalian host cell such that the gene may be expressed by the host cell comprise a promoter and the said gene and includes a dominant activator sequence capable of eliciting host cell-type restricted, integration site independent, copy number dependent expression of the said gene.

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