Expression of pace in host cells and methods of use thereof

Details Expression of pace in host cells and methods of use thereof Expression of pace in host cells and methods of use thereof

C - Chemistry, Metallurgy

12

N

C12N 15/11 (2006.01) C07K 14/755 (2006.01) C12N 1/15 (2006.01) C12N 1/19 (2006.01) C12N 1/21 (2006.01) C12N 5/10 (2006.01) C12N 9/64 (2006.01) C12P 21/02 (2006.01)

Patent

CA 2096418

Compositions and methods are provided for endopeptidase production and for enhanced efficiencies of processing heter- ologous precursor polypeptides to mature polypeptides, including proteins requiring gamma-carboxylation for biological activity. These compositions and methods utilize recombinant PACE, a mammalian endopeptidase that is specific for dibasic amino acid sites.

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