Expression of pertussis holotoxin in bordetella pertussis

Details Expression of pertussis holotoxin in bordetella pertussis Expression of pertussis holotoxin in bordetella pertussis

C - Chemistry, Metallurgy

12

N

C12N 15/31 (2006.01) C07H 21/04 (2006.01) C07K 14/235 (2006.01) C12N 1/21 (2006.01) C12Q 1/68 (2006.01)

Patent

CA 2118824

EXPRESSION OF PERTUSSIS HOLOTOXIN IN BORDETELLA PERTUSSIS Abstract of the Disclosure The invention relates to a cloned region of the Bordetella pertussis genome located 3' of the ptx operon encoding factors required for expression, assembly or secretion of pertussis holotoxin. Methods for obtaining increased levels of holotoxin production using homologous and heterologous hosts are also described.

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