Expression of polypeptides

Details Expression of polypeptides Expression of polypeptides

C - Chemistry, Metallurgy

12

N

C12N 15/85 (2006.01) A01K 67/027 (2006.01) C12N 9/72 (2006.01) C12N 15/62 (2006.01) C12N 15/90 (2006.01) C12P 21/00 (2006.01)

Patent

CA 2055500

2055500 9113151 PCTABS00007 This invention relates to processes and intermediates for improving the level of production of a desired polypeptide in a recombinant host whose genome has integrated into it an island of expression comprising in the 5' to 3' direction, a 5' flanking region, the heterologous polypeptide encoding sequence and a 3' flanking region. The island of expression of this invention permits the expression of the integrated heterologous DNA sequence to be substantially dependent on its copy number and to be substantially independent of its position of integration in the host genome.

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