C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 1/21 (2006.01) A61K 39/08 (2006.01) A61K 39/112 (2006.01) A61K 39/116 (2006.01) A61K 39/295 (2006.01) C07K 14/005 (2006.01) C07K 14/025 (2006.01) C07K 14/035 (2006.01) C07K 14/09 (2006.01) C07K 14/195 (2006.01) C07K 14/255 (2006.01) C07K 14/33 (2006.01) C07K 19/00 (2006.01) C12N 9/52 (2006.01) C12N 15/31 (2006.01) C12N 15/33 (2006.01) C12N 15/55 (2006.01) C12N 15/62 (2006.01) C12N 15/63 (2006.01) C12N 15/74 (2006.01)
Patent
CA 2141427
The invention provides a DNA molecule comprising a promoter sequence op-erably linked to a DNA se-quence encoding first and second proteins linked by a hinge region wherein. in that the promoter sequence can be one having activity which is induced in response to a change in the surrounding environment and the first protein can be Tetanus toxin C fragment or one or more epitopes thereof. The inven-tion also provides intermedi-ate molecules having a prom-oter operably linked to a DNA sequence encoding a first antigenic sequence and a hinge region, and at or adja-cent the 3'-end thereof one or more restriction sites for the introduction of a second anti-genic sequence. In addition, the invention provides repli-cable expression vectors containing the DNA fusion proteins expressed therefrom, bacterial transformed with the vectors and the use of the bacteria, in vaccines.
Chatfield Steven Neville
Dougan Gordon
Hormaeche Carlos Estenio
Khan Mohammed Anjam
Villarreal-Ramos Bernardo
Medeva Holdings B.v.
Peptide Therapeutics Limited
Ridout & Maybee Llp
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